SIS works by providing a natural, extracellular matrix with a three-dimensional structure that acts as a scaffold for host tissue remodeling.

	After SIS is implanted, tissues adjacent to the SIS matrix deliver cells and nutrients to the implant site.
	The cells rapidly invade the SIS material. Capillary growth follows, and allows nutrients to enter the matrix.
	SIS is remarkably strong at the time of implant, and is gradually remodeled while the host system reinforces and rebuilds the damaged site with host tissue.
	The integrity of the repair is maintained and the new tissue becomes completely "self."

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