BIOCHEMISTRY

Brennan EP, Reing J, Chew D, Myers-Irvin JM, Young EJ, Badylak SF. Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix. Tissue Engineering 2006; 12:2949-2955.

de Paula M, Goissis G, Martins VC, da Silva Trindade JC. Injectable gels of anionic collagen: Rhamsan composites for plastic correction: Preparation, characterization, and rheological properties. J Biomed Mater Res 2005; 75B:393-399.

Freytes DO, Tullius RS, Badylak SF. Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder. J Biomed Mater Res B Appl Biomater 2006; 78:327-333.

Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials 2006; 27:3675-3683.

Grimes M, Pembroke JT, McGloughlin T. The effect of choice of sterilisation method on the biocompatibility and biodegradability of SIS (small intestinal submucosa). Biomedical Materials and Engineering 2005; 15:65-71.

Hodde J, Janis A, Ernst D, Zopf D, Sherman D, Johnson C. Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture. J Mater Sci Mater Med 2007; 18:537-543.

Hodde J, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: Part II. Bioactivity and matrix interaction. J Mater Sci Mater Med 2007; 18:545-550.

Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. Tissue Engineering 1996; 2:209-217.

Hurst RE, Bonner RB. Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy. J Biomater Sci Polym Ed 2001; 12:1267-1279.

Hyun H, Lee JH, Seo KS, et al. The release of albumin from PLGA and PCL wafers containing natural and synthetic additives for protein delivery. Polymer Korea 2005; 29:468-474.

Kasyanov V, Isenburg J, Draughn RA,et al. Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials 2006; 27:745-751.

Kim MS, Seo KS, Hyun H, Kim SK, Khang G, Lee HB. Sustained release of bovine serum albumin using implantable wafers prepared by MPEG-PLGA diblock copolymers. Int J Pharm 2005; 304:165-177.

Lee SJ, Lee IW, Lee YM, Lee HB, Khang G. Macroporous biodegradable natural/synthetic hybrid scaffolds as small intestine submucosa impregnated poly(D,L-lactide-co-glycolide) for tissue-engineered bone. J Biomater Sci Polym Ed 2004; 15:1003-1017.

Luo JC, Yang ZM. Preparation and characteristics of small intestinal submucosa. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2003; 17:425-428.

McPherson TB, Badylak SF. Characterization of fibronectin derived from porcine small intestinal submucosa. Tissue Engineering 1998; 4:75-83.

Mondalek FG, Zhang YY, Kropp B, et al. The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field. J Nanobiotechnology 2006; 4:4.

Record RD, Hillegonds D, Simmons C, et al. In vivo degradation of 14C-labeled small intestinal submucosa (SIS) when used for urinary bladder repair. Biomaterials 2001; 22:2653-2659.

Rickey FA, Elmore D, Hillegonds D, Badylak S, Record R, Simmons-Byrd A. Re-generation of tissue about an animal-based scaffold: AMS studies of the fate of the scaffold. Nucl Instrum Methods Phys Res 2000; 172:904-909.

Seddighi MR, Griffon DJ, Constable PD, Martin-Jimenez T. Effects of porcine small intestinal submucosa on elution characteristics of gentamicin-impregnated plaster of Paris. Am J Vet Res 2007; 68:171-177.

Yue TW, Chien WC, Tseng SJ, Tang SC. EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction. Biomaterials 2007; 28:2350-2357.

CELL BIOLOGY

Androjna C, Spragg RK, Derwin KA. Mechanical conditioning of cell-seeded small intestine submucosa: A potential tissue-engineering strategy for tendon repair. Tissue Engineering 2007 Jan 1 [Epub].

Badylak S, Liang A, Record R, Tullius R, Hodde J. Endothelial cell adherence to small intestinal submucosa: An acellular bioscaffold. Biomaterials 1999; 20:2257-2263.

Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol 2002:13; 377-383.

Badylak SF. In Vivo Studies to Evaluate Tissue Engineering Techniques. Ann N Y Acad Sci 2002; 961:302-304.

Badylak SF, Grompe M, Caplan AI, Greisler HP, Guldberg RE, Taylor DA. In Vivo Remodeling Breakout Session Summary. Ann N Y Acad Sci 2002; 961:319-322.

Badylak SF, Park K, Peppas N, McCabe G, Yoder M. Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. Exp Hematol 2001; 29:1310-1318.

Badylak SF, Record R, Lindberg K, Hodde J, Park K. Small intestinal submucosa: a substrate for in vitro cell growth. J Biomater Sci Polym Ed 1998; 9:863-877.

Brightman AO, Rajwa BP, Sturgis JE, McCallister ME, Robinson JP, Voytik-Harbin SL. Time-lapse confocal reflection microscopy of collagen fibrillogenesis and extracellular matrix assembly in vitro. Biopolymers 2000; 54:222-234.

Cen S, Li W, Huang F.  [Preliminary research on construction of artificial esophagus with cultured squamous epithelial cells and myoblast cells seeded on small intestinal submucosa]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20:1040-1043.

Elkin M, Miao HQ, Nagler A, Aingorn et al. Halofuginone: a potent inhibitor of critical steps in angiogenesis progression. FASEB J 2000; 14:2477-2485.

Fan WJ, Yang ZM, Li XQ, Wang Z, Zhi W, Qiu L. [The experiment of porcine keratinocytes cultured on porcine small intestinal submucosa in vitro]. Zhonghua Zheng Xing Wai Ke Za Zhi 2006; 22:220-222.

Gilbert TW, Stewart-Akers AM, Badylak SF. A quantitative method for evaluating the degradation of biologic scaffold materials. Biomaterials 2007; 28:147-150.

Gilbert TW, Stewart-Akers AM, Sydeski J, Nguyen TD, Badylak SF, Woo SL. Gene expression by fibroblasts seeded on small intestinal submucosa and subjected to cyclic stretching. Tissue Engineering 2007 Apr 26 [Epub].

Hodde J, Record R, Badylak S. Assessment of Angiogenesis in an In Vitro Three-Dimensional Assay. Cardiac and Vascular Regeneration 2000; 4:236-245.

Hodde J, Record R, Tullius R, Badylak S. Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. Biomaterials 2002; 23:1841-1848.

Hodde JP, Hiles MC. Bioactive FGF-2 in Sterilized Extracellular Matrix. Wounds 2001; 13:195-201.

Hodde JP, Record RD, Liang HA, Badylak SF. Vascular endothelial growth factor in porcine-derived extracellular matrix. Endothelium 2001; 8:11-24.

Hodde JP, Record RD, Tullius RS, Badylak SF. Retention of Endothelial Cell Adherence to Porcine-Derived Extracellular Matrix after Disinfection and Sterilization. Tissue Engineering 2002; 8:225-234.

Hou J, Xiang HL, Feng XS, Tian XH, Pang XL, Teng Y. [Co-culture of cryopreserved rat islets with small intestinal submucosa]. Nan Fang Yi Ke Da Xue Xue Bao 2006; 26:1121-1123.

Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA. A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Letters 2005; 217:171-180.

Hurst RE, Kyker KD, Bonner RB, Bowditch RD, Hemstreet GP. Matrix-dependent Plasticity of the Malignant Phenotype of Bladder Cancer Cells. Anticancer Res 2003; 23:3119-3128.

Johnston DE, Boughner DR, Cimini M, Rogers KA. Radial artery as an autologous cell source for valvular Tissue Engineering efforts. J Biomed Mater Res 2006; 78:383-393.

Kyker KD, Culkin DJ, Hurst RE. A model for 3-dimensional growth of bladder cancers to investigate cell-matrix interactions. Urol Oncol 2003; 21:255-261.

Lakey JR, Woods EJ, Zieger MA, et al. Improved islet survival and in vitro function using solubilized small intestinal submucosa. Cell Tissue Bank 2001; 2:217-224.

Lakshmanan Y, Frimberger D, Gearhart JD, Gearhart JP. Human embryoid body-derived stem cells in co-culture with bladder smooth muscle and urothelium. Urology 2005; 65:821-826.

Li F, Li W, Johnson S, Ingram D, Yoder M, Badylak S. Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells. Endothelium 2004; 11:199-206.

Li H, Ji T, Xu LQ, Hu YJ, Li SY, Zhang CP. [Study on the osteogenesis ability of co-culturing bone marrow stromal cells (BMSCs) and small intestinal submucosa.] Shanghai Kou Qiang Yi Xue 2006; 15:167-171.

Lindberg K, Badylak SF. Porcine small intestinal submucosa (SIS): A bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane proteins. Burns 2001; 27:254-266

Long RA, Nagatomi J, Chancellor MB, Sacks MS. The role of MMP-I up-regulation in the increased compliance in muscle-derived stem cell-seeded small intestinal submucosa. Biomaterials 2006; 27:2398-2404.

Lu SH, Cannon TW, Chermanski C, et al. Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotine receptors. Urology 2003; 61:1285-1291.

Lu SH, Sacks MS, Chung SY, et al. Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution. Biomaterials 2005; 26:443-449.

McDevitt CA, Wildey GM, Cutrone RM. Transforming growth factor-B1 in a sterilized tissue derived from the pig small intestine submucosa. J Biomed Mater Res 2003; 67A:637-640.

Ninan L, Stroshine RL, Wilker JJ, Shi R. Adhesive strength and curing rate of marine mussel protein extracts on porcine small intestinal submucosa. Acta Biomaterials 2007 Apr 13; [Epub].

Pariente JL, Kim BS, Atala A. In vitro biocompatibility assessment of naturally derived and synthetic biomaterials using normal human urothelial cells. J Biomed Mater Res 2001; 55:33-39.

Park KS, Jin CM, Yun SJ, et al. Effects of SIS sponge and bone marrow-derived stem cells on the osteogenic differentiation for tissue engineered bone. Polymer Korea 2005; 29:501-507.

Rosenthal EL, Wax MK, Anderson P, Kulecz-Martin M. The Mucosal Invasion Model A Novel In Vitro Model for Evaluating the Invasive Behavior of Mucocutaneous Malignancies. Arch Otolaryngol Head Neck Surg 2001; 127:1467-1470.

Sarikaya A, Record R, Wu CC, Tullius B, Badylak S, Ladisch M. Antimicrobial Activity Associated with Extracellular Matrices. Tissue Engineering 2002; 8:63-71.

Su Y, Zeng BF, Zhang CQ, Zhang KG, Xie XT. Study of biocompatibility of small intestinal submucosa (SIS) with Schwann cells in vitro. Brain Res 2007; 1145:41-47.

Tian XH, Xue WJ, Ding XM, et al. Small intestinal submucosa improves islet survival and function during in vitro culture. World J Gastroenterol 2005; 11:7378-7383.

Tian XH, Xue WJ, Pang XL, Teng Y, Tian PX, Feng XS. Effect of small intestinal submucosa on islet recovery and function in vitro culture. Hepatobiliary Pancreat Dis Int 2005; 4:524-529.

Voytik-Harbin SL. Three-Dimensional Extracellular Matrix Substrates for Cell Culture. Methods Cell Biol 2001; 63:561-581.

Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem 1997; 67:478-491.

Voytik-Harbin SL, Brightman AO, Waisner B, Lamar CH, Badylak SF. Application and evaluation of the alamarBlue assay for cell growth and survival of fibroblasts. In Vitro Cellular and Development Biology - Animal 1998; 34:239-246.

Voytik-Harbin SL, Brightman AO, Waisner BZ, Robinson JP, Lamar CH. Small intestinal submucosa: A tissue-derived extracellular matrix that promotes tissue-specific growth and differentiation of cells in vitro. Tissue Engineering 1998; 4:157-174.

Voytik-Harbin, SL, Rajwa B, Robinson JP. Three-Dimensional Imaging of Extracellular Matrix and Extracellular Matrix-Cell Interactions. Methods Cell Biol 2001; 63:583-597.

Woods AM, Rodenberg EJ, Hiles MC, Pavalko FM. Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells. Biomaterials 2004; 25:515-525.

Woods EJ, Walsh CM, Sidner RA, et al. Enhanced recovery of cryopreserved islets using SIS. Transplant Proc 2004; 36:1139-1142.

Xiaohui T, Wujun X, Xiaoming D, et al. Small intestinal submucosa improves islet survival and function in vitro culture. Transplant Proc 2006; 38:1552-1558.

Zhang KG, Zeng BF, Zhang CQ. [Periosteum construction in vitro by small intestinal submucosa combined with bone marrow mesenchymal stem cell]. Zhonghua Wai Ke Za Zhi 2005; 43:1594-1597.

Zhang Y, Kropp BP, Moore P, et al. Coculture of bladder urothelial and smooth muscle cells on small intestinal submucosa: potential applications for tissue engineering technology. J Urol 2000; 164:928-935.

DERMATOLOGY

Cimini M, Boughner DR, Ronald JA, Johnston DE, Rogers KA. Dermal fibroblasts cultured on small intestinal submucosa: Conditions for the formation of a neotissue. J Biomed Mater Res 2005; 75:895-906.

Fan W, Yang Z, Luo J, Huang Y, Li X, Wang Z. [A comparative study on acellular small intestinal submucosa and acellular amnion as dressings for traumatic skin defects]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20:155-160.

Hodde JP, Ernst DMJ, Hiles MC. An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix. J Wound Care 2005; 14:23-25.

Holt TM, Mann FA. Carbon Dioxide Laser Resection of a Distal Carpal Pilomatricoma and Wound Closure Using Swine intestinal Submucosa in a Dog. J Am Anim Hosp Assoc 2002; 39:499-505.

Kim MS, Hong KD, Shin HW, et al. Preparation of porcine small intestinal submucosa sponge and their application as a wound dressing in full-thickness skin defect of rat. Int J Biol Macromol 2005; 36:54-60.

Prevel CD, Eppley BL, Summerlin DJ, et al. Small intestinal submucosa: utilization as a wound dressing in full-thickness rodent Wounds Ann Plast Surg 1995; 35:381-388.

Suckow MA, Hodde JP, Wolters WR, Hiles MC. Use of porcine renal capsule matrix as a full-thickness dermal wound healing material in rats. J Wound Care 2005; 14:137-140.

Werier J, Ferguson P, Bell R, et al. Model of radiation-impaired healing of a deep excisional wound. Wound Repair Reg 2006; 14:498-505.

GASTROENTEROLOGY

Ansaloni L, Bonasoni P, Cambrini P, et al. Experimental evaluation of Surgisis as scaffold for neointestine regeneration in a rat model. Transplant Proc 2006; 38:1844-1848.

Badylak S, Meurling S, Chen M, Spievack A, Simmons-Byrd A. Resorbable bioscaffold for esophageal repair in a dog model. J Pediatr Surg 2000; 35:1097-1103.

Badylak SF, Vorp DA, Spievack AR, et al. Esophageal reconstruction with ECM and muscle tissue in a dog model. J Surg Res 2005; 128:87-97.

Chen MK, Badylak SF. Small bowel tissue engineering using small intestinal submucosa as a scaffold. J Surg Res 2001; 99:352-358.

Chen MK, Beierle EA. Animal models for intestinal tissue engineering. Biomaterials 2004; 25:1675-1681.

de la Fuente SG, Gottfried MR, Lawson DC, Harris MB, Mantyh CR, Pappas TN. Evaluation of Porcine-Derived Small Intestine Submucosa as a Biodegradable Graft for Gastrointestinal Healing. J Gastrointest Surg 2003; 7:96-101.

De Ugarte DA, Choi E, Weitzbuch H, et al. Mucosal regeneration of a duodenal defect using small intestine submucosa. Am Surg 2004; 70:49-51.

Demirbilek S, Kanmaz T, Ozardali I, Edali MN, Yucesan S. Using porcine small intestinal submucosa in intestinal regeneration. Pediatr Surg Int 2003; 19:588-592.

Downey DM, Harre JG, Dolan JR. Increased burst pressure in gastrointestinal staple-lines using reinforcement with a bioprosthetic material. Obes Surg 2005; 15:1379-1383.

el-Ghoul W. The effects of combined liquid and membrane barriers in prevention of post-operative intra-abdominal adhesions after experimental jejunal anastomosis in dogs. Deutsche tierarztliche Wochenschrift. 2005; 112:3-10.

Felsher J, Rosen M, Farres H, Walsh RM. A novel endolaparoscopic intragastric partitioning for treatment of morbid obesity. Surg Laparosc Endosc Percutan Tech 2004; 14:243-246.

Gubbels SP, Richardson M, Trune D, Bascom DA, Wax MK. Tracheal reconstruction with porcine small intestine submucosa in a rabbit model. Otolaryngol Head Neck Surg 2006; 134:1028-1035.

Jernigan TW, Croce MA, Cagiannos C, Shell DH, Handorf CR, Fabian TC. Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination. Ann Surg 2004; 239:733-740.

Kajitani M, Wadia Y, Xie H, et al. Use of a new elastin patch and glue for repair of a major duodenal injury. ASAIO J 2000; 46:409-414.

Konstantinovic ML, Lagae P, Zheng F, Verbeken EK, De Ridder D, Deprest JA. Comparison of host response to polypropylene and non-cross-linked porcine small intestine serosal-derived collagen implants in a rat model. Brit J Obstet Gynaecol 2005; 112:1554-1560.

Lopes MF, Cabrita A, Ilharco J, Pessa P, Patricio J. Grafts of porcine intestinal submucosa for repair of cervical and abdominal esophageal defects in the rat. J Invest Surg 2006; 19:105-111.

Marsh RE, Awad ZT, Cornet DA, Tomonaga T, Smyrk T, Filipi CJ. Endoscopic SIS injection into the lower oesophageal sphincter in dogs. Ir J Med Sci 2003; 172:20-23.

Pinheiro JS, Correa JL, Cohen RV, Novaes JA, Schiavon CA. Staple line reinforcement with new biomaterial increased burst strength pressure: An animal study. Surg Obes Relat Dis 2006; 2:397-399.

Pye PK, Dada T, Duthie G, Phillips K. Surgisis mesh: a novel approach to repair of a recurrent rectovaginal fistula. Dis Colon Rectum 2004; 47:1554-1556.

Ringel RL, Kahane JC, Hillsamer PJ, Lee AS, Badylak SF. The application of tissue engineering procedures to repair the larynx. J Speech Lang Hear Res 2006; 49:194-208.

Rosen M, Ponsky J, Petras R, Fanning A, Brody F, Duperior F. Small intestinal submucosa as a bioscaffold for biliary tract regeneration. Surg 2002; 132:480-486.

Souza Filho ZA, Greca FH, Rocha SL, et al. [Porcine submucosa graft for the treatment of duodenal injuries in dogs.] Acta Chirgica Brasiliera 2005; 20:394-398.

Souza Filho ZA, Ioshii SO, Greca FH, et al. Emprego da submucosa de intestino delgado porcina no reparo de lesões do esôfago cervical. Estudo experimental em cães [Small intestine submucosa for repair of cervical esophageal lesions in a dog model]. Acta Cirurgica Brasileira 2003; 18:224-231.

Ueno T, Oga A, Takahashi T, Pappas TN. Small Intestinal Submucosa (SIS) in the repair of a cecal wound in unprepared bowel in rats. J Gastrointest Surg 2007 May 3 [Epub].

Wang ZQ, Watanabe Y, Noda T, Yoshida A, Oyama T, Toki A. Morphologic evaluation of regenerated small bowel by small intestinal submucosa. J Pediatr Surg 2005; 40:1898-1902.

Wang ZQ, Watanabe Y, Toki A. Experimental assessment of small intestinal submucosa as a small bowel graft in a rat model. J Pediatr Surg 2003; 38:1596-1601.

Zeng YJ, Quao AK, Yu JD, et al. Collagen fiber angle in the submucosa of small intestine and its application in gastroenterology. World J Gastroenterol 2003; 9:804-807.

Zhang L, Liu Z, Cui P, Zhao D, Chen W. SIS with tissue-cultured allogenic cartilages patch tracheoplasty in a rabbit model for tracheal defect. Acta Otolaryngol 2007; 127:631-636.

GENERAL SURGERY

Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R. Morphologic Study of Small Intestinal Submucosa as a Body Wall Repair Device. J Surg Res 2002; 103:190-202.

Badylak S, Kokini K, Tullius B, Whitson B. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res 2001; 99:282-287.

Clark KM, Lantz GC, Salisbury SK, Badylak SF, Hiles MC, Voytik SL. Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs. J Surg Res 1996; 60:107-114.

Dalla Vecchia L, Engum S, Kogon B, Jensen E, Davis M, Grosfeld J. Evaluation of small intestine submucosa and acellular dermis as diaphragmatic prostheses. J Pediatr Surg 1999; 34:167-171.

De Ugarte DA, Puapong D, Roostaeian J, et al. Surgisis patch tracheoplasty in a rodent model for tracheal stenosis. J Surg Res 2003; 112:65-69.

Desai KM, Diaz S, Dorward IG, et al.  Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model. Surg Endosc 2006; 20:1693-1697.

Gomez NA, Zapatier JA, Vargas PE. Small intestinal submucosa as a bioscaffold for biliary tract regeneration (Letter to the editor). Surgery 2004; 135:460.

Hodde JP, Suckow MA, Wolter WR, Hiles MC. Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar rats. J Surg Res 2004; 120:189-194

Huber JE, Spievack A, Simmons-Byrd A, Ringel RL, Badylak, S. Extracellular matrix as a scaffold for laryngeal reconstruction. Ann Otol Rhinol Laryngol 2003; 112:428-433.

Ko R, Kazacos EA, Snyder S, Ernst DM, Lantz GC. Tensile strength comparison of small intestinal submucosa body wall repair. J Surg Res 2006; 135:9-17.

Lai JY, Chang PY, Lin JN. Body wall repair using small intestinal submucosa seeded with cells. J Pediatr Surg 2003; 38:1752-1755.

Ma X, Zhang C, Zhang K. [Experimental study on repairing rabbit femoral condyles defect by small intestinal submucosa and HA-TCP compositions at different ratios.] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20:1061-1065.

Pandit AS, Henry JA. Design of surgical meshes - an engineering perspective. Technol Health Care 2004; 12:51-65.

Poulose BK, Scholz S, Moore DE, et al. Physiologic Properties of Small Intestine Submucosa. J Surg Res 2005; 123:262-267.

Prevel CD, Eppley BL, Summerlin DJ, Jackson JR, McCarty M, Badylak SF. Small intestinal submucosa: utilization for repair of rodent abdominal wall defects. Ann Plast Surg 1995; 35:374-380.

Ross JW. Pelvic Floor Hernias: Tissue Repair or Replacement? Laparoscopy and SLS Report 2003; 2:12-16.

Sandoval JA, Lou D, Engum SA, et al. The whole truth: comparative analysis of diaphragmatic hernia repair using 4-ply vs 8-ply small intestinal submucosa in a growing animal model. J Pediatr Surg 2006; 41:518-523.

Soiderer EE, Lantz GC, Kazacos EA, Hodde JP, Wiegand RE. Morphologic Study of Three Collagen Materials for Body Wall Repair. J Surg Res 2004; 118:161-175.

Stoll MR, Cook JL, Pope ER, Carson WL, Kreeger JM. The Use of Porcine Small Intestinal Submucosa as a Biomaterial for Perineal Herniorrhapy in the Dog. Vet Surg 2002; 31:379-390.

Walter CJ, Beral DL, Drew P. Optimum mesh and port sizes for laparoscopic incisional hernia repair. J Laparoendosc Adv Surg Tech 2007 Feb; 17:58-63.

Winkler JT, Swaim SF, Sartin EA, Henderson RA, Welch JA. The Effect of a Porcine-Derived Small Intestinal Submucosa Product on Wounds with Exposed Bone in Dogs. Vet Surg 2002; 31:541-551.

Yamakado K, Pavcnik D, Uchida BT, et al. Biliary small intestinal submucosa covered Z-stents: preliminary results in an animal model. Radiology Oncology 2001; 35:1-10.

Zhang X, Luo J, Yang Z. [Elementary evaluation of small intestinal submucosa and polypropylene mesh used for repairing abdominal wall defect in rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2005; 19:574-577.

IMMUNOLOGY

Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a th2-restricted immune response. Transplantation 2001; 71:1631-1340.

Allman AJ, McPherson TB, Merrill LC, Badylak SF, Metzger DW. The Th2-Restriced Immune Response to Xenogeneic Small Intestinal Submucosa Does Not Influence Systemic Protective Immunity to Viral and Bacterial Pathogens. Tissue Engineering 2002; 8:53-62.

Harlan DM, Karp CL, Matzinger P, Munn DH, Ransohoff RM, Metzger DW. Immunological Concerns with Bioengineering Approaches. Ann N Y Acad Sci 2002; 961:323-330.

McPherson TB, Liang H, Record RD, Badylak SF. Gal alpha (1,3) Gal epitope in porcine small intestinal submucsa (SIS). Tissue Engineering 2000; 6:233-239.

Metzger DW. Immune Responses to Tissue-Engineered Extracellular Matrix Used as a Bioscaffold. Ann N Y Acad Sci 2002; 961:335-336.

Palmer EM, Baum LG, Van Seventer GA. Small Intestinal Submucosa Induces Loss of Mitochondrial Integrity and Caspase-Dependent Apoptosis in Human T Cells. Tissue Engineering 2003; 9:307-314.

Palmer EM, Beilfuss BA, Nagai T, Semnani RT, Badylak SF, Van Seventer GA. Human Helper T Cell Activation and Differentiation Is Suppressed by Porcine Small Intestinal Submucosa. Tissue Engineering 2002; 8:893-900.

Raeder RH, Badylak SF, Sheehan C, Kallakury B, Metzger DW. Natural anti-galactose alpha1,3 galctose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts Transpl Immunol 2002; 10:15-24.

MATERIAL PROPERTIES

Abraham GA, Murray J, Billiar K, Sullivan SJ. Evaluation of the porcine intestinal collagen layer as a biomaterial. J Biomed Mater Res 2000; 51:442-452.

Billiar K, Murray J, Laude D, Abraham G, Bachrach N. Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa. J Biomed Mater Res 2001; 56:101-108.

Ferrand BK, Kokini K, Badylak SF, Geddes LA, Hiles MC, Morff RJ. Directional porosity of porcine small-intestinal submucosa. J Biomed Mater Res 1993; 27:1235-1241.

Freytes DO, Badylak SF, Webster TJ, Geddes LA, Rundell AE. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials 2004; 25:2353-2361.

Freytes DO, Rundell AE, Vande Geest J, Vorp DA, Webster TJ, Badylak SF. Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test. Biomaterials 2005; 26:5518-5531.

Gilbert TW, Sacks MS, Grashow JS, Woo SL, Badylak SF, Chancellor MB. Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretch. J Biomech Eng 2006; 128:890-898.

Gilbert TW, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF. Production and characterization of ECM powder: implications for tissue engineering applications. Biomaterials 2005; 26:1431-1435.

Gloeckner DC, Sacks MS, Billiar KL, Bachrach N. Mechanical evaluation and design of a multilayered collagenous repair biomaterial. J Biomed Mater Res 2000; 52:365-373.

Hiles MC, Badylak SF, Geddes LA, Kokini K, Morff RJ. Porosity of porcine small-intestinal submucosa for use as a vascular graft. J Biomed Mater Res 1993; 27:139-144.

Hodde J, Hiles M. Virus Safety of a Porcine-Derived Medical Device: Evaluation of a Viral Inactivation Method. Biotechnol Bioeng 2002; 79:211-216.

Leng Y, Ding Z, Gong L. [Elastic modulus of small intestinal submucosa]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20:292-294.

Nicoson ZR, Buckley CA. Bond Strength of Fibrin Glue between Layers of Porcine Small Intestine Submucosa (SIS). Biomed Sci Instrum 2002; 38:179-184.

Obermiller FJ, Hodde JP, McAlexander CS, Kokini K, Badylak SF. A comparison of suture retention strengths for three biomaterials. Med Sci Monit 2004; 10:PI1-5.

Raghavan D, Kropp BP, Lin HK, Zhang Y, Cowan R, Madihally SV. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res 2005; 73A:90-96.

Roeder R, Wolfe J, Lianakis N, Hinson T, Geddes LA, Obermiller J. Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts. J Biomed Mater Res 1999; 47:65-70.

Sacks MS, Gloeckner GC. Quantification of the fiber architecture and biaxial mechanical behavior of porcine intestinal submucosa. J Biomed Mater Res 1999; 46:1-10.

Whitson BA, Cheng BC, Kokini K, et al. Multilaminate resorbable biomedical device under biaxial loading. J Biomed Mater Res 1998; 43:277-281.

NEUROLOGY

Cobb MA, Badylak SF, Janas W, Boop FA. Histology after dural grafting with small intestinal submucosa. Surg Neurol 1996; 46:389-394.

Cobb MA, Badylak SF, Janas W, Simmons-Byrd A, Boop FA. Porcine small intestinal submucosa as a dural substitute. Surg Neurol 1999; 51:99-104.

Eggink AJ, Roelofs LA, Feitz WF, et al. In utero repair of an experimental neural tube defect in a chronic sheep model using biomatrices. Fetal Diagnostics and Therapeutics 2005; 20:335-340.

Eggink AJ, Roelofs LA, Lammens MM, et al. Histological evaluation of acute covering of an experimental neural tube defect with biomatrices in fetal sheep. Fetal Diagnostics and Therapeutics 2006; 21:210-216.

Hadlock TA, Sundback CA, Hunter DA, Vacanti JP, Cheney ML. A new artificial nerve graft containing rolled schwann cell monolayers. Microsurgery 2001; 21:96-101.

Haq I, Cruz-Almeida Y, Siqueira EB, Norenberg M, Green BA, Levi AD. Postoperative fibrosis after surgical treatment of the porcine spinal cord: a comparison of dural substitutes. J Neurosurg Spine 2005; 2:50-54.

Smith R, Wiedl C, Chubb P, Greene C. Role of small intestine submucosa (SIS) as a nerve conduit: Preliminary report. J Invest Surg 2004; 17:339-344.

Xei X, Zhang C, Su Y. [Comparison between effects of small intestinal submucosa graft and inside-out vein graft on repairing peripheral nerve defects]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007; 21:149-153.

OBSTETRICS AND GYNECOLOGY

Binkert CA, Pavcnik D, Andrews RT, et al. Fallopian tube occlusion with use of a small intestine submucosa device: evaluation in a rabbit model. J Vas Interv Rad 2004; 15:609-613.

Taveau JW, Tartaglia M, Buchannan D, et al. Regeneration of Uterine Horn Using Porcine Small Intestinal Submucosa Grafts in Rabbits. J Invest Surg 2004; 17:81-92.

OPHTHALMOLOGY

Briksawan P, Wongaumnuaykul S, Tuntivanich P, Tuntivanich N, Sunthornvipat K. The use of porcine small intestinal submucosa (PSIS) in a canine deep corneal ulcer. Thai Journal of Veterinary Medicine 2003; 33:101-106.

Duffy MT, Bloom JN, McNally-Heintzelman KM, Heintzelman DL, Soller EC, Hoffman GT. Sutureless ophthalmic surgery: a scaffold-enhanced bioadhesive technique. J AAPOS 2005; 9:315-320.

Griguer F, Raymond I, Regnier A. Preliminary evaluation of the biocompatibility of the small intestinal submucosa (SIS) biomaterial with the rabbit cornea. Rev Med Vet 2001; 152:597-604.

Vanore M, Chahory S, Payen G, Clerc B. Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats. Vet Ophthalmol 2007; 10:93-99.

ORTHOPEDICS

Aiken SW, Badylak SF, Toombs JP, et al. Small intestinal submucosa as an intra-articular ligamentous graft material: a pilot study in dogs. Vet Comp Orthop Traumatol 1994; 7:124-128.

Arnoczky SP. Building a Meniscus Biologic Considerations. Clin Orthop Relat Res 1999; 367S:S244-S253.

Badylak S, Arnoczky S, Plouhar P, et al. Naturally occurring extracellular matrix as a scaffold for musculoskeletal repair. Clin Orthop Relat Res 1999; 367S:S333-S343.

Badylak SF, Tullius R, Kokini K, et al. The use of xenogeneic small intestinal submucosa as a biomaterial for Achille's tendon repair in a dog model. J Biomed Mater Res 1995; 29:977-985.

Badylak SF, Wu CC, Bible M, McPherson E. Host Protection against Deliberate Bacterial Contamination of an Extracellular Matrix Bioscaffold versus Dacron Mesh in a Dog Model of Orthopedic Soft Tissue Repair. J Biomed Mater Res 2003; 67B:648-654.

Beatty MW, Ojha AK, Cook JL, et al. Small Intestinal Submucosa versus Salt-Extracted Polyglycolic Acid-Poly-L-lactic acid: A Comparison of Neocartilage Formed in Two Scaffold Materials. Tissue Engineering 2002; 8:955-968.

Cook JL, Fox DB, Malaviya P, et al. Evaluation of small intestinal submucosa grafts for meniscal regeneration in a clinically relevant posterior meniscectomy model in dogs. J Knee Surg 2006; 19:159-167.

Cook JL, Fox DB, Malaviya P, et al. Long-term Outcome for Large Meniscal Defects Treated With Small Intestinal Submucosa in a Dog Model. Am J Sports Med 2006; 34:32-42.

Cook JL, Tomlinson JL, Arnoczky SP, Fox DB, Cook CR, Kreeger JM. Kinetic study of the replacement of porcine small intestinal submucosa grafts and the regeneration of meniscal-like tissue in large avascular meniscal defects in dogs. Tissue Engineering 2001; 7:321-334.

Cook JL, Tomlinson JL, Kreeger JM, Cook C. Induction of meniscal regeneration in dogs using a novel biomaterial. Am J Sports Med 1999; 27:658-665.

Crow BD, Haltom JD, Carson WL, Greene WB, Cook JL. Evaluation of a novel biomaterial for intrasubstance muscle laceration repair. J Orthop Res 2007; 25:396-403.

Dejardin LM, Arnoczky SP, Clarke RB. Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs. J Biomed Mater Res 1999; 46:203-211.

Dejardin LM, Arnoczky SP, Ewers BJ, Haut RC, Clarke RB. Tissue-Engineered Rotator Cuff Tendon Using Porcine Small Intestine Submucosa Histologic and Mechanical Evaluation in Dogs. Am J Sports Med 2001; 29:175-184.

Fox DB, Cook JL, Arnoczky SP, et al. Fibrochondrogenesis of Free Intraarticular Small Intestinal Submucosa Scaffolds. Tissue Engineering 2004; 10:129-137.

Gastel JA, Muirhead WR, Lifrak JT, Fadale PD, Hulstyn MJ, Labrador DP. Meniscal tissue regeneration using a collagenous biomaterial derived from porcine small intestine submucosa. Arthroscopy 2001; 17:151-159.

Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, Badylak SF. Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair. J Bone Joint Surg 2007; 89:621-630.

Hodde JP, Badylak SF, Shelbourne KD. The effect of range of motion on remodeling of small intestinal submucosa (SIS) when used as an achilles tendon repair material in the rabbit. Tissue Engineering 1997; 3:27-37.

Khang G, Rhee JM, Shin P, et al. Preparation and Characterization of Small Intestine Submucosa Powder Impregnated Poly(L-lactide) Scaffolds: The Application for Tissue Engineered Bone and Cartilage. Macromolecular Research 2002; 10:158-167.

Ledet EH, Carl AL, DiRisio DJ, et al. A pilot study to evaluate the effectiveness of small intestinal submucosa used to repair spinal ligaments in the goat. Spine J 2002; 2:188-196.

Liang R, Woo SL, Takakura Y, Moon DK, Jia F, Abramowitch SD. Long-term effects of porcine small intestine submucosa on the healing of medial collateral ligament: A functional tissue engineering study. J Orthop Res 2006; 24:811-819.

Moore DC, Pedrozo HA, Crisco JJ, Ehrlich MG. Preformed grafts of porcine small intestine submucosa (SIS) for bridging segmental bone defects. J Biomed Mater Res 2004; 69A:259-266.

Musahl V, Abramowitch SD, Gilbert TW, et al. The use of porcine small intestinal submucosa to enhance the healing of the medial collateral ligament - a functional tissue engineering study in rabbits. J Orthop Res 2004; 22:214-2202.

Owen TJ, Lantz GC, Hiles MC, VanVleet J, Martin BR, Geddes LA. Calcification potential of small intestinal submucosa in a rat subcutaneous model. J Surg Res 1997; 71:179-186.

Peel SA, Chen H, Renlund R, Badylak SF, Kandel RA. Formation of a SIS-cartilage composite graft in vitro and its use in the repair of articular cartilage defects. Tissue Engineering 1998; 4:143-155.

Schlegel TF, Hawkins RJ, Lewis CW, Motta T, Turner AS. The effects of augmentation with swine small intestine submucosa on tendon healing under tension: Histologic and mechanical evaluations in sheep. Am J Sports Med 2006; 34:275-280.

Suckow MA, Voytik-Harbin SL, Terril LA, Badylak SF. Enhanced bone regeneration using porcine small intestinal submucosa. J Invest Surg 1999; 12:277-287.

Sun T, Yang Z, Xie H. [Experimental study on constructing muscle tissue in rabbits with tissue engineering methods]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005; 19:364-368.

Welch JA, Montgomery RD, Lenz SD, Plouhar P, Shelton WR. Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs. Am J Vet Res 2002; 63:427-431.

Woo SL, Takakura Y, Liang R, Jia F, Moon DK. Treatment with bioscaffold enhances the fibril morphology and the collagen composition of healing medial collateral ligament in rabbits. Tissue Engineering 2006; 12:159-166.

Zalavras CG, Gardocki R, Huang E, Stevanovic M, Hedman T, Tibone J. Reconstruction of large rotator cuff tendon defects with porcine small intestinal submucosa in an animal model. J Shoulder Elbow Surg 2006; 15:224-231.

Zantop T, Gilbert TW, Yoder MC, Badylak SF. Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction. J Orthop Res 2006; 24:1299-1309.

PLASTIC SURGERY

Macleod TM, Williams G, Sanders R, Green CJ. Histological evaluation of Permacol as a subcutaneous implant over a 20-week period in the rat model. Br J Plast Surg 2005; 58:518-532.

Pribitkin EA, Ambro BT, Bloeden E, O’Hara BJ. Rabbit ear cartilage regeneration with a small intestinal submucosa graft. Laryngoscope 2004; 114:S1-S19.

Spiegel JH, Kessler JL. Tympanic membrane perforation repair with acellular porcine submucosa. Otol Neurotol 2005; 26:563-566.

Spiegel JH. Egan TJ. Porcine Small Intestine Submucosa for Soft Tissue Augmentation. Dermatol Surg 2004; 30:1486-1490.

Zhang F, Ji Y, Pickus EJ, Oswald T, Gui L, Lineaweaver WC. Cartilage Repair Using Porcine Small Intestinal Submucosa in a Rabbit Model:  Preliminary Study. Timisoara Med J 2004; 54:24-27.

Zhang F, Zhu C, Oswald T, Lei MP, Lineaweaver WC. Porcine small intestinal submucosa as a carrier for skin flap prefabrication. Ann Plast Surg 2003; 51:488-492.

REVIEW

Badylak S. Extracellular matrix as a scaffold for tissue engineering in veterinary medicine: Applications to soft tissue healing. Clinical Techniques in Equine Practice 2004; 3:173-181.

Badylak SF. Small intestinal submucosa (SIS): a biomaterial conducive to smart tissue remodeling in Tissue Engineering: Current Perspectives. Bell E (ed).  Burkhauser Publishers, Cambridge, MA 1993, pp. 179-189.

Badylak SF. Xenogeneic extracellular matrix as a scaffold for tissue reconstruction Transplant Immunol 2004; 12:367-377.

Badylak SF. Regenerative medicine and developmental biology: The role of the extracellular matrix. Anat Rec B New Anat 2005; 287B:36-41.

Bell E. Strategy for the selection of scaffolds for tissue engineering. Tissue Engineering 1995; 1:163-179.

Dedecker F, Grynberg M, Staerman F. [Small intestinal submucosa (SIS): prospects in urogenital surgery]. Progres en Urologie 2005; 15:405-410.

Downey DM, Ali S, Saxe JM, Goldblatt MI, Dolan JP. Gastrointestinal staple line reinforcement. Surgical Techniques International 2007; 16:55-60.

Eisenbud D, Huang NF, Luke S, Silberklang M. Skin Substitutes and Wound Healing: Current Status and Challenges. Wounds 2004; 16:2-17.

Falke GF, Atala A. Reconstruccion de tejidos y organos utilizando ingenieria tisular. Actualizacion 2000; 92:103-115.

Granderath FA, Carlson MA, Champion JK, et al. Prosthetic closure of the esophageal hiatus in large hiatal hernia repair and laparoscopic antireflux surgery. Surg Endosc 2006; 20:367-379.

Hiles M, Hodde J. Tissue engineering a clinically useful extracellular matrix biomaterial. Int Urogynecol J Pelvic Floor Dysfunct 2006; 17S7:39-43.

Hodde J. Naturally Occurring Scaffolds for Soft Tissue Repair and Regeneration. Tissue Engineering 2002; 8:295-308.

Hodde JP, Johnson CE. Extracellular matrix as a strategy for treating chronic wounds. Am J Clin Dermatol 2007; 8:61-66.

Hodde JP. Extracellular matrix as a bioactive material for soft tissue reconstruction. ANZ J Surg 2006; 76:1096-1100.

Jankowski R, Pruchnic R, Hiles M, Chancellor MB. Advances toward tissue engineering for the treatment of stress urinary incontinence. Rev Urol 2004; 6:51-57.

Kobashi KC, Hsiao KC, Govier FE. Suitability of different sling materials for the treatment of female stress urinary incontinence. Nat Clin Pract Urol 2005; 2:84-91.

Langer R, Vacanti JP, Vacanti CA, Atala A, Freed LE, Vunjak-Novakovic G. Tissue Engineering: Biomedical Applications. Tissue Engineering 1995; 1:151-161.

Novitsky YW, Harrell AG, Hope WM, Kercher KW, Heniford BT. Meshes in hernia repair. Surgical Techniques International 2007; 16:123-127.

Staack A, Hayward SW, Baskin LS, Cunha GR. Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration. Differentiation 2005; 73:121-133.

Stock U, Vacanti J. Tissue Engineering: Current State and Prospects Annual Reviews Medicine 2001; 52:443-451.

Trabuco EC, Klingele CJ, Gebhart JB. Xenograft use in reconstructive pelvic surgery: a review of the literature. Int Urogynecol J Pelvic Floor Dysfunct 2007; 18:555-563.

Vieller GR. Innovations in ventral hernia repair. Surgical Techniques International 2007; 16:117-122.

THORACIC SURGERY

Downey DM, Michel M, Harre JG, Pratt JW. Functional assessment of a new staple line reinforcement in lung resection. J Surg Res 2006; 131:49-52.

UROLOGY

Badylak SF, Kropp B, McPherson T, Liang H, Snyder PW. Small intestinal submucosa: A rapidly resorbed bioscaffold for augmentation cystoplasty in a dog model. Tissue Engineering 1998; 4:379-387.

Baumert H, Simon P, Hekmati M, et al. Development of a seeded scaffold in the great omentum: Feasibility of an in vivo bioreactor for bladder tissue engineering. Eur Urol 2006 Dec 5; [Epub].

Caione P, Capozza N, Zavaglia D, Palombaro G, Boldrini R. In vivo bladder regeneration using small intestinal submucosa: experimental study. Pediatr Sur Int 2006; 22:593-599.

Calvano CJ, Moran ME, Parekh A, Desai PJ, Cisek LJ. Laparoscopic augmentation cystoplasty using the novel biomaterial Surgisis: small-intestinal submucosa. J Endourol 2000; 14:213-217.

Campodonico F, Benelli R, Michelazzi A, Ognio E, Toncini C, Maffezzini M. Bladder Cell Culture on Small Intestinal Submucosa as a Bioscaffold: Experimental Study on Engineered Urothelial Grafts. Eur Urol 2004; 46:531-537.

Cannon TW, Sweeney DD, Conway DA, et al. A tissue-engineered suburethral sling in an animal model of stress urinary incontinence. BJU Int 2005; 96:664-669.

Cheng EY, Kropp BP. Urologic tissue engineering with small-intestinal submucosa: potential clinical applications. World J Urol 2000; 18:26-30.

Chung SY, Krivorov NP, Rausei V, et al. Bladder reconstitution with bone marrow derived stem cells seeded on small intestinal submucosa improves morphological and molecular composition. J Urol 2005; 174:353-359.

Desgrandchamps F. Biomaterials in functional reconstruction. Curr Opin Urol 2000; 10:201-206.

Duchene DA, Jacomides L, Ogan K, et al. Ureteral replacement using small-intestinal submucosa and a collagen inhibitor in a porcine model. J Endourol 2004; 18:507-511.

El-Assmy A, El-Hamid MA, Abo-Elghar ME, Hafez AT. Single-layer small intestinal submucosa or tunica vaginalis flap for correcting penile chordee. BJU Int 2004; 94:1097-1101.

El-Assmy A, Hafez AT, El-Sherbiny MT, et al. Use of Single Layer Small Intestinal Submucosa for Long Segment Ureteral Replacement:: A Pilot Study. J Urol 2004; 171:1939-1942.

Elbahnasy AM, Shalhav A, Hoenig DM, Figenshau R, Clayman RV. Bladder wall substitution with synthetic and nonintestinal organic materials. J Urol 1998; 159:628-637.

Faramarzi-Roques R, Malgat M, Desgrandchamps F, Ballanger P, Mazat JP. Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa. BJU Int 2004; 94:419-423.

Frimberger D, Morales N, Shamblott M, Gearhart JD, Gearhart JP, Lakshmanan Y. Human embryoid body-derived stem cells in bladder regeneration using rodent model. Urology 2005; 65:827-832.

Furness PD, Kolligian ME, Lang SJ, Kaplan WE, Kropp BP, Cheng EY. Injectable small intestinal submucosa: preliminary evaluation for use in endoscopic urological surgery. J Urol 2000; 164:1680-1685.

Greca FH, Noronha L, Bendhack M, Feres A, Soccol A, Duda JR. Use of small intestine submucosa as ureteral allograft in pigs. Int Braz J Urol 2004; 30:327-335.

Grossklaus DJ, Shappell SB, Adams MC, Brock JW, Pope JC. Small intestinal submucosa as a urethral coverage layer. J Urol 2001; 166:636-639.

Hafez AT, El-Assmy A, El-Hamid MA. 4 layer versus 1 layer small intestinal submucosa for correction of penile chordee: experimental study in a rabbit model. J Urol 2004; 171:2489-2491.

Huang X, Luo J, Liao Y, Qu Y, Yang Z. [Study on small intestinal submucosa as repair materials in urethral reconstruction]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20:206-209.

Jaffe JS, Ginsberg PC, Yanoshak SJ, et al. Ureteral Segment Replacement Using a Circumferential Small-Intestinal Submucosa Xenogenic Graft. J Invest Surg 2001; 14:259-265.

Jankowski R, Pruchnic R, Hiles M, Chancellor MB. Advances toward tissue engineering for the treatment of stress urinary incontinence. Rev Urol 2004; 6:51-57.

Kim BS, Baez CE, Atala A. Biomaterials for tissue engineering. World J Urol 2000; 18:2-9.

Knapp PM, Lingeman JE, Siegel YI, Badylak SF, Demeter RJ. Biocompatibility of small-intestinal submucosa in urinary tract as augmentation cystoplasty graft and injectable suspension. J Endourol 1994; 8:125-130.

Kropp BP. Developmental aspects of the contractile smooth muscle component in small intestinal submucosa regenerated urinary bladder. Advances in Bladder Research 1999; 462:129-135.

Kropp BP. Small-intestinal submucosa for bladder augmentation: a review of preclinical studies. World J Urol 1998; 16:262-267.

Kropp BP, Badylak S, Thor KB. Regenerative bladder augmentation: a review of the initial preclinical studies with porcine small intestinal submucosa. Adv Exp Med Biol 1995; 385:229-235.

Kropp BP, Cheng EY. Bioengineering organs using small intestinal submucosa scaffolds: in vivo tissue-engineering technology. J Endourol 2000; 14:59-62.

Kropp BP, Cheng EY, Lin HK, Zhang Y. Reliable and reproducible bladder regeneration using unseeded distal small intestinal submucosa. J Urol 2004; 172:1710-1713.

Kropp BP, Cheng EY, Pope JC, et al. Use of Small Intestinal Submucosa for Corporal Body Grafting in Cases of Severe Penile Curvature. J Urol 2002; 168:1742-1745.

Kropp BP, Eppley BL, Prevel CD, et al. Experimental assessment of small intestinal submucosa as a bladder wall substitute. Urology 1995; 46:396-400.

Kropp BP, Ludlow JK, Spicer D, etal. Rabbit urethral regeneration using small intestinal submucosa onlay grafts. Urology 1998; 52:138-142.

Kropp BP, Pope JC. Small intestinal submucosa: A novel substance for the study of cellular interaction and regeneration in the bladder. Dialogues in Pediatric Urology 1997; 20:1-8.

Kropp BP, Rippy MK, Badylak SF, et al. Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations. J Urol 1996; 155:2098-2104.

Kropp BP, Sawyer BD, Shannon HE, et al. Characterization of small intestinal submucosa regenerated canine detrusor: Assessment of reinnervation, in vitro compliance and contractility. J Urol 1996; 156:599-607.

Kubricht WS 3rd, Williams BJ, Eastham JA, Venable DD. Tensile Strength of Cacaveric Fascia Lata Compared to Small Intestinal Submucosa Using Suture Pull Through Analysis. J Urol 2001; 165:486-490.

Landman J, Olweny E, Collyer W, et al. Small intestine submucosa: intrinsic and asastomotic tensile strength of SIS using laser welding, fibrin glue, vascular closure staples, endo-GIA staples and sutures. Minimally Invasive Therapy & Allied Technology 2000; 9:375-378.

Landman J, Olweny E, Sundaram CP, et al. Laparoscopic mid sagittal hemicystectomy and bladder reconstruction with small intestinal submucosa and reimplantation of ureter into small intestinal submucosa: 1-year followup. J Urol 2004; 171:2450-2455.

Leungwattanakij S, Pummangura N, Ratana-Olarn K. Penile enhancement using a porcine small intestinal submucosa graft in a rat model. International Journal of Impotence Research 2006; 18:39-43.

Liatsikos EN, Dinlenc CZ, Kapoor R, et al. Laparoscopic Ureteral Reconstruction with Small Intestinal Submucosa. J Endourol 2001; 15:217-220.

Liatsikos EN, Dinlenc CZ, Kapoor R, et al. Ureteral Reconstruction: Small Intestine Submucosa for the Management of Strictures and Defects of the Upper Third of the Ureter. J Urol 2001; 165:1719-1723.

Magunna, C, Spellmeyer, O, Hund M, Nickel R. Augmentation der Harnblase nach radikaler Resektion: erste klinische Erfahrungen mit einem lyophilisierten Xenoimplantat aus der Dunndarmsubmukosa des Schweins bei Hund und Katze. Kleintierpraxis 1999; 44:809-821.

Metwalli AR, Colvert JR, Kropp BP. Tissue engineering in Urology: Where are we going? Curr Urol Rep 2003; 4:156-163.

Monga M, Cosgrove D, Zupkas P, et al. Small Intestinal Submucosa as a Tunica Albuginea Graft Material. J Urol 2002; 168:1215-1221.

Nuininga JE, van Moerkerk H, Hanssen A, et al. Rabbit urethra replacement with a defined biomatrix or small intestinal submucosa. Eur Urol 2003; 44:266-274.

Nuininga JE, van Moerkerk H, Hanssen A, et al. A rabbit model to tissue engineer the bladder Biomaterials 2004; 25:1657-1661.

Paterson RF, Lifshitz DA, Beck SD, et al. Multilayered Small Intestinal Submucosa is Inferior to Autologous Bowel for Laparoscopic Bladder Augmentation. J Urol 2002; 168:2253-2257.

Pope JC, Davis MM, Smith ER, et al. The ontogeny of canine small intestinal submucosa regenerated bladder. J Urol 1997; 158:1105-1110.

Portis AJ, Elbahnasy AM, Shalhav AL, et al. Laparoscopic augmentation cystoplasty with different biodegradable grafts in an animal model. J Urol 2000; 164:1405-1411.

Portis AJ, Elbahnasy AM, Shalhav AL, et al. Laparoscopic midsagittal hemicystectomy and  replacement of bladder wall with small intestinal submucosa and reimplantation of ureter into graft. J Endourol 2000; 14:203-211.

Rabah DM, Spiess PE, Begin LR, Corcos J. Tissue reaction of the rabbit urinary bladder to tension-free vaginal tape and porcine small intestinal submucosa. BJU Int 2002; 90:601-606.

Reddy PP, Barrieras DJ, Wilson G, et al. Regeneration of functional bladder substitutes using large segment acellular matrix allografts in a porcine model. J Urol 2000; 164:936-941.

Roemer FD. There isn't an ideal smooth-surface material--yet: the history and future of urologic materials. J Endourol 2000; 14:1-4.

Rotariu P, Yohannes P, Alexianu M, et al. Reconstruction of rabbit urethra with Surgisis^®  small intestinal submucosa. J Endourol 2002; 16:617-620.

Schultheiss D, Gabouev AI, Cebotari S, et al. Biological vascularized matrix for bladder tissue engineering: matrix preparation, reseeding technique and short-term implantation in a porcine model. J Urol 2005; 173:276-280.

Shalhav AL, Elbahnasy AM, Bercowsky E, et al. Laparoscopic replacement of urinary tract segments using biodegradable materials in a large-animal model. J Endourol 1999; 13:241-244.

Shokeir AA. Bladder regeneration: between the idea and reality. BJU Int 2002; 89:186-193.

Smith TG, Gettman M, Lindberg G, Napper C, Pearle MS, Cadeddu JA. Ureteral Replacement Using Porcine Small Intestine Submucosa in a Porcine Model. Urology 2002; 60:931-934.

Sofer M, Rowe E, Forder DM, Denstedt JD. Ureteral Segmental Replacement Using Multilayer Porcine Small-Intestinal Submucosa. J Endourol 2002; 16:27-31.

Thiel M, Rodrigues Palma PC, Riccetto CL, Dambros M, Netto NR Jr. A stereological analysis of fibrosis and inflammatory reaction induced by four different synthetic slings. BJU Int  2005; 95:833-837.

Vaught JD, Kropp BP, Sawyer BD, et al. Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: Functional innervation and receptor expression. J Urol 1996; 155:374-378.

Wilson TS, Lemack GE, Zimmern PE. Management of intrinsic sphincteric deficiency in women. J Urol 2003; 169:1662-1669.

Wunsch L, Ehlers EM, Russlies M. Matrix testing for urothelial tissue engineering. Eur J Pediatr Surg 2005; 15:164-169.

Xie H, Shaffer BS, Wadia Y, Gregory KW. Use of reconstructed small intestine submucosa for urinary tract replacement. ASAIO J 2000; 46:268-272.

Yohannes P, Rotariu P, Liatsikos E, et al. Role of acellular collagen matrix (Surgisis^®) in the endoscopic management of ureteropelvic junction obstruction. J Endourol 2002; 16:549-556.

Zhang Y, Lin HK, Frimberger D, Epstein RB, Kropp BP. Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder. BJU Int 2005; 96:1120-1125.

Zhang, Y, Kropp, BP, Lin, HK, Cowan, R, Cheng, EY. Bladder regeneration with cell-seeded small intestinal submucosa. Tissue Engineering 2004; 10:181-187.

VASCULAR SURGERY

Badlyak S, Obermiller J, Geddes L, Matheny R. Extracellular Matrix for Myocardial Repair Heart Surg Forum 2003; 6:E20-E26.

Badylak SF, Coffey AR, Lantz GC, Tacker WA, Geddes LA. Comparison of the resistance to infection of intestinal submucosa arterial autografts versus polytetrafluoroethylene arterial prostheses in a dog model. J Vasc Surg 1994; 3:465-472.

Badylak SF, Kochupura PV, Cohen IS, et al. The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium. Cell Transplant 2006; 15 Suppl 1:S29-40.

Badylak SF, Lantz GC, Coffey A, Geddes LA. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res 1989; 47:74-80.

Baltoyannis G, Mitsis M, Nathanael C, et al. Submucosa of canine small intestine as an alternative medium-diameter autogenous arterial graft International. Angiology 2000; 19:280-284.

Brountzos E, Pavcnik D, Timmermans HA, et al. Remodeling of suspended small intestinal submucosa venous valve: an experimental study in sheep to assess the host cells' origin. J Vasc Interv Rad  2003; 14:349-356.

Cooley BC. Invited discussion of Experimental evaluation of small intestinal submucosa as a microvascular graft material (C.D. Prevel, B.L. Eppley, M. McCarty, J.R. Jackson, S.L. Voytik, M.C. Hiles, S.F. Badylak, page 586). Microsurgery 1994; 15:592-593.

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VETERINARY

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